Jacob Vogel

Our research

Research in the Dementia Multi-Omics and Neuroimaging (DeMON) lab focuses on aging and neurodegenerative disease, where we take advantage of large data resources to model disease progression and discover contributions to disease pathogenesis. Some of the lab’s principal research avenues include characterizing individual difference in disease progression, predicting the neurobiological progression of neurodegenerative diseases, and modeling the earliest biological changes that lead to neurodegenerative syndromes. Our work achieves these goals by blending large neuroimaging and multi-omic datasets, and applying to these datasets supervised and unsupervised methods in statistical learning and disease progression modeling.

Aims

• Characterizing individual difference in disease progression, predicting the neurobiological progression of neurodegenerative diseases.
• Modelling the earliest biological changes that lead to neurodegenerative syndromes.

Strengths of the group

Our research group is privileged with a large network of collaborators that help push forward the lab's research goals by providing both expert domain knowledge and rare datasets. This includes the Swedish BioFINDER study, which is one of the premier neurodegenerative datasets in the world. The group boasts a sophistication in many statistical approaches and an expertise in many types of datasets.

Finally, we have a commitment to open science, FAIR principals and contributing to the greater research community.

Impact

As a member of the Diagnostics and Precision Medicine arm of DDLS, my lab's research is focused on questions that can provide insights into disease neurobiology while simultaneously providing immediate clinical value. Part of our research pertains to the development of diagnostic and predictive tools that can be feasibly employed in clinical situations.

In addition, our lab's focus on human data means that our research has a fairly short road to clinical translation. One of our overall goals is to provide a comprehensive biological model of how diseases like Alzheimer's disease progress, signposting the relevant biological changes that occur along these trajectories. This will allow not only monitoring of disease progression, but also predictions about clinical progression and insights into aspects of disease physiology that may be targetable for treatment.

| Research Output

Affiliations

• SciLifeLab & SciLifeLab & Wallenberg National Program for Data-Driven Life Science
• Clinical Memory Research Unit, Department of Clinical Sciences, Lund University

Social media

• Twitter
• The DeMON lab website (currently under development)